Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications

Abstract Microfluidic processes are of great interest for the production nanoparticles with reproducible properties. However, in real systems, it is difficult to completely exclude incidental larger particles, which can contaminate product or clog downstream process modules. A class microfluidic filters was devised eliminating particulate contamination multistage continuous‐flow processes. To achieve high throughput and filtration efficiency, a high‐surface‐area filter an application‐adapted bonding method developed. As model application, efficiency analyzed lipid made by antisolvent precipitation results were compared requirements European US guidelines.